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Article

A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.

Journal of molecular biology - 15 Dec 2006

Li Zhe, Lukasik Steven M, Liu Yizhou, Grembecka Jolanta, Bielnicka Izabela, Bushweller John H, Speck Nancy A

Abstract excerpt

The Runt domain is the DNA binding domain of the core binding factor (CBF) Runx subunits. The CBFs are transcription factors that play critical roles in hematopoiesis, bone, and neuron development in mammals. A common non-DNA binding CBFbeta subunit heterodimerizes with the Runt domain of the Runx proteins and allosterically regulates its affinity for DNA. Previous NMR dynamics studies suggested a model whereby...

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Identifiers

PMID: 17059830
DOI: 10.1016/j.jmb.2006.10.002
PMCID: PMC1783549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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