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Article

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

The Journal of biological chemistry - 29 Aug 2003

Li Zhe, Yan Jiangli, Matheny Christina J, Corpora Takeshi, Bravo Jerónimo, Warren Alan J, Bushweller John H, Speck Nancy A

Abstract excerpt

Core-binding factors (CBFs) are a small family of heterodimeric transcription factors that play critical roles in hematopoiesis and in the development of bone, stomach epithelium, and proprioceptive neurons. Mutations in CBF genes are found in leukemias, bone disorders, and gastric cancer. CBFs consist of a DNA-binding CBF alpha subunit and a non-DNA-binding CBF beta subunit. DNA binding and heterodimerization...

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Identifiers

PMID: 12807882
DOI: 10.1074/jbc.M303973200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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