Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamic Local Polymorphisms in the Gbx1 Homeodomain Induced by DNA Binding.

Structure (London, England : 1993) - 2 Aug 2016

Proudfoot Andrew, Geralt Michael, Elsliger Marc-Andre, Wilson Ian A, Wüthrich Kurt, Serrano Pedro

Abstract excerpt

The Gastrulation Brain Homeobox 1 (Gbx1) gene encodes the Gbx1 homeodomain that targets TAATTA motifs in double-stranded DNA (dsDNA). Residues Glu17 and Arg52 in Gbx1 form a salt bridge, which is preserved in crystal structures and molecular dynamics simulations of homologous homeodomain-DNA complexes. In contrast, our nuclear magnetic resonance (NMR) studies show that DNA binding to Gbx1 induces dynamic local...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Homeodomain Proteins
Share to Molecular Docking Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Dynamics Simulation

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Protein Conformation, alpha-Helical

Share to Protein Conformation, beta-Strand

Share to Protein Interaction Domains and Motifs

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 27396829
DOI: 10.1016/j.str.2016.05.013
PMCID: PMC5109927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamic Local Polymorphisms in the Gbx1 Homeodomain Induced by DNA Binding.PMID 27396829Read ↗

Structural effect of the L16Q, K50E, and R53P mutations on homeodomain of pituitary homeobox protein 2.Semantic proximity Read ↗

Congenital heart disease missense mutations in the TBX5 DNA-binding domain alter thermal stability and DNA-binding affinitySemantic proximity Read ↗

Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome.Semantic proximity Read ↗

Structural Basis for DNA Recognition by FOXG1 and the Characterization of Disease-causing FOXG1 Mutations.Semantic proximity Read ↗

Cancer-related mutations in BRCA1-BRCT cause long-range structural changes in protein-protein binding sites: a molecular dynamics study.Semantic proximity Read ↗

DNA breathing dynamics distinguish binding from nonbinding consensus sites for transcription factor YY1 in cells.Semantic proximity Read ↗

Mutagenesis of the Runt Domain Defines Two Energetic Hot Spots for Heterodimerization with the Core Binding Factor β SubunitSemantic proximity Read ↗

Altering the RNA-binding mode of the U1A RBD1 protein.Semantic proximity Read ↗

A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.Semantic proximity Read ↗

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.Semantic proximity Read ↗

Computational modeling of the bHLH domain of the transcription factor TWIST1 and R118C, S144R and K145E mutants.Semantic proximity Read ↗

Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9 A resolution: structural basis for enhanced affinity and altered specificity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.