Article
Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP.
Biophysical journal - 15 Sept 2015
Muratcioglu Serena, Presman Diego M, Pooley John R, Grøntved Lars, Hager Gordon L, Nussinov Ruth, Keskin Ozlem, Gursoy Attila
Abstract excerpt
The glucocorticoid receptor (GR) is a steroid-hormone-activated transcription factor that modulates gene expression. Transcriptional regulation by the GR requires dynamic receptor binding to specific target sites located across the genome. This binding remodels the chromatin structure to allow interaction with other transcription factors. Thus, chromatin remodeling is an essential component of GR-mediated...
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