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Mutagenesis of the Runt Domain Defines Two Energetic Hot Spots for Heterodimerization with the Core Binding Factor β Subunit

1 Aug 2003

Abstract excerpt

Core-binding factors (CBFs) are a small family of heterodimeric transcription factors that play critical roles in several developmental pathways and in human disease. Mutations in CBF genes are found in leukemias, bone disorders, and gastric cancers. CBFs consist of a DNA-binding CBF alpha subunit (Runx1, Runx2, or Runx3) and a non-DNA-binding CBF beta subunit. CBF alpha binds DNA in a sequence-specific manner,...

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PMID: 12807883
DOI: 10.1074/jbc.m303972200

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Related research

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Mutagenesis of the Runt Domain Defines Two Energetic Hot Spots for Heterodimerization with the Core Binding Factor β SubunitPMID 12807883Read ↗

Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha.Semantic proximity Read ↗

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.Semantic proximity Read ↗

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Structural Analyses of DNA Recognition by the AML1/Runx-1 Runt Domain and Its Allosteric Control by CBFβSemantic proximity Read ↗

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A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cellsSemantic proximity Read ↗

Three classes of mutations in the A subunit of the CCAAT-binding factor CBF delineate functional domains involved in the three-step assembly of the CBF-DNA complex.Semantic proximity Read ↗

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