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Article

Functional mutagenesis of AML1/RUNX1 and PEBP2 beta/CBF beta define distinct, non-overlapping sites for DNA recognition and heterodimerization by the Runt domain.

Journal of molecular biology - 27 Apr 2001

Nagata T, Werner M H

Abstract excerpt

The Runt domain family of transcription factors play key roles in transcriptional regulation of definitive hematopoiesis and osteogenesis. This transcription factor family is characterized by a DNA-binding alpha-subunit harboring the Runt domain and a secondary subunit, beta, which binds to the Runt domain and enhances its interaction with DNA. Missense mutations in the Runt domain from either the blood or...

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Source

Identifiers

PMID: 11327761
DOI: 10.1006/jmbi.2001.4596

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional mutagenesis of AML1/RUNX1 and PEBP2 beta/CBF beta define distinct, non-overlapping sites for DNA recognition and heterodimerization by the Runt domain.PMID 11327761Read ↗

Structural Analyses of DNA Recognition by the AML1/Runx-1 Runt Domain and Its Allosteric Control by CBFβSemantic proximity Read ↗

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Mutagenesis of the Runt Domain Defines Two Energetic Hot Spots for Heterodimerization with the Core Binding Factor β SubunitSemantic proximity Read ↗

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Mammalian runt‐domain proteins and their roles in hematopoiesis, osteogenesis, and leukemiaSemantic proximity Read ↗

The role of a Runt domain transcription factor AML1/RUNX1 in leukemogenesis and its clinical implicationsSemantic proximity Read ↗

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