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Article

The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp.

Nature structural biology - 1 Apr 2001

Bravo J, Li Z, Speck N A, Warren A J

Abstract excerpt

We have determined the structure, at 2.6 A resolution, of the AML1 (Runx1) Runt domain--CBF beta--DNA ternary complex, the most common target for mutations in human leukemia. The structure reveals that the Runt domain DNA binding mechanism is unique within the p53 family of transcription factors....

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Source

Identifiers

PMID: 11276260
DOI: 10.1038/86264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11276260-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp.PMID 11276260Read ↗

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