Article

Sequence determinants of allosteric back-to-front control of the Arf nucleotide switch

2025-04-18

Abstract excerpt

<title>Abstract</title> <p>Unlike AI-based protein structure prediction, the sequence determinants of protein dynamics, and thus function, remain elusive. The nucleotide switch in Arf GTPases involves a massive structural change, which we showed recently in Arf1 is facilitated by a dynamic molten globule ensemble. Here we investigate the unresolved sequence-dynamics paradigm by comparing Arf1 and Arf6 using a com...

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Literature Corpus work: 501e0805-00d8-5cf2-b75d-3c7a914d7e05
DOI: 10.21203/rs.3.rs-6466232/v1

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