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Article

The Runt domain of AML1 (RUNX1) binds a sequence-conserved RNA motif that mimics a DNA element.

RNA (New York, N.Y.) - 1 Jul 2013

Fukunaga Junichi, Nomura Yusuke, Tanaka Yoichiro, Amano Ryo, Tanaka Taku, Nakamura Yoshikazu, Kawai Gota, Sakamoto Taiichi, Kozu Tomoko

Abstract excerpt

AML1 (RUNX1) is a key transcription factor for hematopoiesis that binds to the Runt-binding double-stranded DNA element (RDE) of target genes through its N-terminal Runt domain. Aberrations in the AML1 gene are frequently found in human leukemia. To better understand AML1 and its potential utility for diagnosis and therapy, we obtained RNA aptamers that bind specifically to the AML1 Runt domain. Enzymatic probing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23709277
DOI: 10.1261/rna.037879.112
PMCID: PMC3683927

Genes

RUNX1

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The Runt domain of AML1 (RUNX1) binds a sequence-conserved RNA motif that mimics a DNA element.PMID 23709277Read ↗

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