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Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

12 Apr 2004

Abstract excerpt

Mutations in the gene parkin in humans (PARK2) are responsible for a large number of familial cases of autosomal-recessive Parkinson disease. We have isolated a Drosophila homolog of human PARK2 and characterized its expression and null phenotype. parkin null flies have 30% lower mass than wild-type controls which is in part accounted for by a reduced cell size and number. In addition, these flies are infertile,...

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PMID: 15073152
DOI: 10.1242/dev.01095

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Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stressPMID 15073152Read ↗

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