Article
T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2006
Taqueti Viviany R, Grabie Nir, Colvin Richard, Pang Hong, Jarolim Petr, Luster Andrew D, Glimcher Laurie H, Lichtman Andrew H
Abstract excerpt
CD8+ CTL contribute to the pathogenesis of myocarditis and cardiac allograft rejection. Using a transgenic model of myocarditis, we examined the role of the transcription factor T-bet in the differentiation of pathogenic cardiac Ag-specific CTL. We demonstrate that T-bet-deficient CTL are significantly impaired in their ability to cause disease, despite intact proliferation and activation phenotypes. In the...
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