P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes.

doi:10.1172/JCI94524

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Article

P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes.

The Journal of clinical investigation - 1 Aug 2018

D'Addio Francesca, Vergani Andrea, Potena Luciano, Maestroni Anna, Usuelli Vera, Ben Nasr Moufida, Bassi Roberto, Tezza Sara, Dellepiane Sergio, El Essawy Basset, Iascone Maria, Iacovoni Attilio, Borgese Laura, Liu Kaifeng, Visner Gary, Dhe-Paganon Sirano, Corradi Domenico, Abdi Reza, Starling Randall C, Folli Franco, Zuccotti Gian Vincenzo, Sayegh Mohamed H, Heeger Peter S, Chandraker Anil, Grigioni Francesco, Fiorina Paolo

Abstract excerpt

Purinergic receptor-7 (P2X7R) signaling controls Th17 and Th1 generation/differentiation, while NOD-like receptor P3 (NLRP3) acts as a Th2 transcriptional factor. Here, we demonstrated the existence of a P2X7R/NLRP3 pathway in T cells that is dysregulated by a P2X7R intracellular region loss-of-function mutation, leading to NLRP3 displacement and to excessive Th17 generation due to abrogation of the...

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Identifiers

PMID: 30010623
DOI: 10.1172/JCI94524
PMCID: PMC6063506

Genes

NLRP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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