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Article

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy.

The Journal of experimental medicine - 22 Dec 2008

Yuan Xueli, Paez-Cortez Jesus, Schmitt-Knosalla Isabela, D'Addio Francesca, Mfarrej Bechara, Donnarumma Michela, Habicht Antje, Clarkson Michael R, Iacomini John, Glimcher Laurie H, Sayegh Mohamed H, Ansari M Javeed

Abstract excerpt

T-bet plays a crucial role in Th1 development. We investigated the role of T-bet in the development of allograft rejection in an established MHC class II-mismatched (bm12 into B6) model of chronic allograft vasculopathy (CAV). Intriguingly, and in contrast to IFN-gamma(-/-) mice that are protecte...

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Identifiers

PMID: 19047438
DOI: 10.1084/jem.20081937
PMCID: PMC2605226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19047438-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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