Article
Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2013
Bedoya Felipe, Cheng Guang-Shing, Leibow Abigail, Zakhary Nardine, Weissler Katherine, Garcia Victoria, Aitken Malinda, Kropf Elizabeth, Garlick David S, Wherry E John, Erikson Jan, Caton Andrew J
Abstract excerpt
We examined the formation, participation, and functional specialization of virus-reactive Foxp3(+) regulatory T cells (Tregs) in a mouse model of influenza virus infection. "Natural" Tregs generated intrathymically, based on interactions with a self-peptide, proliferated in response to a homologous viral Ag in the lungs and, to a lesser extent, in the lung-draining mediastinal lymph nodes (medLNs) of...
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