Article
NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway.
The Journal of biological chemistry - 27 Aug 2004
Jono Hirofumi, Lim Jae Hyang, Chen Lin-Feng, Xu Haidong, Trompouki Eirini, Pan Zhixing K, Mosialos George, Li Jian-Dong
Abstract excerpt
The transcription factor NF-kappaB regulates genes involved in inflammatory and immune responses, tumorigenesis, and apoptosis. In contrast to the pleiotropic stimuli that lead to its positive regulation, the known signaling mechanisms that underlie the negative regulation of NF-kappaB are very few. Recent studies have identified the tumor suppressor CYLD, loss of which causes a benign human syndrome called...
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