Article
Induced CYP1A2 activity as a phenotypic biomarker in humans highly exposed to certain PCBs/PCDFs.
Environmental science & technology - 1 Oct 2006
Lambert George H, Needham Larry L, Turner Wayman, Lai Te Jen, Patterson Donald G, Guo Y Leon
Abstract excerpt
Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) continue to be a worldwide public health concern due to their levels in the environment and humans, and associated adverse health effects. In animals, one of the most sensitive effects of physiologically significant body burdens has been the induction of cytochrome P450 1 (CYP1) family of enzymes. This study examined the...
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