Article

Structural insights into agonist-binding and activation of the human complement C3a receptor

2023-02-09

Abstract excerpt

The complement cascade is an integral part of innate immunity, and it plays a crucial role in our body’s innate immune response including combating microbial infections. Activation of the complement cascade results in the generation of multiple peptide fragments, of which complement C3a and C5a are potent anaphylatoxins. The complement C3a binds and activates a G protein-coupled receptor (GPCR) known as C3aR while...

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Literature Corpus work: 6bd7ac63-7e9f-555f-859e-7beedef95723
DOI: 10.1101/2023.02.09.527835

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