Structural Immunology of Complement Receptors 3 and 4

Abstract excerpt

Complement receptors (CR) 3 and 4 belong to the family of beta-2 (CD18) integrins. CR3 and CR4 are often co-expressed in the myeloid subsets of leukocytes, but they are also found in NK cells and activated T and B lymphocytes. The heterodimeric ectodomain undergo considerable conformational change in order to switch the receptor from a structurally bent, ligand-binding in-active state into an extended,...

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