Article
The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jun 2006
El Bissati Kamal, Zufferey Rachel, Witola William H, Carter Nicola S, Ullman Buddy, Ben Mamoun Choukri
Abstract excerpt
The human malaria parasite Plasmodium falciparum relies on the acquisition of host purines for its survival within human erythrocytes. Purine salvage by the parasite requires specialized transporters at the parasite plasma membrane (PPM), but the exact mechanism of purine entry into the infected erythrocyte, and the primary purine source used by the parasite, remain unknown. Here, we report that transgenic...
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