Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular genetic analysis of purine nucleobase transport in Leishmania major.

Molecular microbiology - 1 Jun 2007

Ortiz Diana, Sanchez Marco A, Pierce Steven, Herrmann Timo, Kimblin Nicola, Archie Bouwer H G, Landfear Scott M

Abstract excerpt

Leishmania major and all other parasitic protozoa are unable to synthesize purines de novo and are therefore reliant upon uptake of preformed purines from their hosts via nucleobase and nucleoside transporters. L. major expresses two nucleobase permeases, NT3 that is a high affinity transporter for purine nucleobases and NT4 that is a low affinity transporter for adenine. nt3((-/-)) null mutant promastigotes were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Genes, Protozoan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Green Fluorescent Proteins

Share to Leishmania major

Share to Mutation

Share to Purines

Source

Identifiers

PMID: 17542917
DOI: 10.1111/j.1365-2958.2007.05730.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular genetic analysis of purine nucleobase transport in Leishmania major.PMID 17542917Read ↗

Purine restriction induces pronounced translational upregulation of the NT1 adenosine/pyrimidine nucleoside transporter in Leishmania major.Semantic proximity Read ↗

Genetic analysis of purine metabolism in Leishmania donovani.Semantic proximity Read ↗

Functional characterization of nucleoside transporter gene replacements in Leishmania donovani.Semantic proximity Read ↗

A conditional mutant deficient in hypoxanthine-guanine phosphoribosyltransferase and xanthine phosphoribosyltransferase validates the purine salvage pathway of Leishmania donovani.Semantic proximity Read ↗

Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant.Semantic proximity Read ↗

IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice.Semantic proximity Read ↗

Amplification of adenine phosphoribosyltransferase suppresses the conditionally lethal growth and virulence phenotype of Leishmania donovani mutants lacking both hypoxanthine-guanine and xanthine phosphoribosyltransferases.Semantic proximity Read ↗

Xanthine phosphoribosyltransferase from Leishmania donovani. Molecular cloning, biochemical characterization, and genetic analysis.Semantic proximity Read ↗

The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparum.Semantic proximity Read ↗

GMP reductase and genetic uncoupling of adenylate and guanylate metabolism in Leishmania donovani parasites.Semantic proximity Read ↗

Functional analysis of an inosine-guanosine transporter from Leishmania donovani. The role of conserved residues, aspartate 389 and arginine 393.Semantic proximity Read ↗

Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.