Article
Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Vasudevan G, Carter N S, Drew M E, Beverley S M, Sanchez M A, Seyfang A, Ullman B, Landfear S M
Abstract excerpt
All parasitic protozoa studied to date are incapable of purine biosynthesis and must therefore salvage purine nucleobases or nucleosides from their hosts. This salvage process is initiated by purine transporters on the parasite cell surface. We have used a mutant line (TUBA5) of Leishmania donova...
Topics
- Amino Acid Sequence
- Animals
- Carrier Proteins
- Cloning, Molecular
- Drug Resistance
- Equilibrative Nucleoside Transporter 1
- Female
- Gene Expression
- Genes, Protozoan
- Humans
- Leishmania donovani
- Membrane Proteins
- Molecular Sequence Data
- Mutation