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Article

Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998

Vasudevan G, Carter N S, Drew M E, Beverley S M, Sanchez M A, Seyfang A, Ullman B, Landfear S M

Abstract excerpt

All parasitic protozoa studied to date are incapable of purine biosynthesis and must therefore salvage purine nucleobases or nucleosides from their hosts. This salvage process is initiated by purine transporters on the parasite cell surface. We have used a mutant line (TUBA5) of Leishmania donovani that is deficient in adenosine/pyrimidine nucleoside transport activity (LdNT1) to clone genes encoding these...

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Identifiers

PMID: 9707568
DOI: 10.1073/pnas.95.17.9873
PMCID: PMC21429

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