Mutagenicity Profile Induced by UVB Light in Human Xeroderma Pigmentosum Group C Cells.

doi:10.1111/php.13516

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Article

Mutagenicity Profile Induced by UVB Light in Human Xeroderma Pigmentosum Group C Cells.

Photochemistry and photobiology - 1 May 2022

Quintero-Ruiz Nathalia, Corradi Camila, Moreno Natália Cestari, de Souza Tiago Antonio, Pereira Castro Ligia, Rocha Clarissa Ribeiro Reily, Menck Carlos Frederico Martins

Abstract excerpt

Nucleotide excision repair (NER) is one of the main pathways for genome protection against structural DNA damage caused by sunlight, which in turn is extensively related to skin cancer development. The mutation spectra induced by UVB were investigated by whole-exome sequencing of randomly selected clones of NER-proficient and XP-C-deficient human skin fibroblasts. As a model, a cell line unable to recognize and...

Topics

DNA Damage
DNA Repair
Humans
Mutagenesis
Mutagens
Mutation
Skin Neoplasms
Ultraviolet Rays
Xeroderma Pigmentosum

Source

Open in PubMed

Identifiers

PMID: 34516658
DOI: 10.1111/php.13516

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