Article
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2011
Delano Matthew J, Thayer Terri, Gabrilovich Sonia, Kelly-Scumpia Kindra M, Winfield Robert D, Scumpia Philip O, Cuenca Alex G, Warner Elizabeth, Wallet Shannon M, Wallet Mark A, O'Malley Kerri A, Ramphal Reuben, Clare-Salzer Michael, Efron Philip A, Mathews Clayton E, Moldawer Lyle L
Abstract excerpt
Sepsis, the systemic inflammatory response to microbial infection, induces changes in both innate and adaptive immunity that presumably lead to increased susceptibility to secondary infections, multiorgan failure, and death. Using a model of murine polymicrobial sepsis whose severity approximates human sepsis, we examined outcomes and defined requirements for survival after secondary Pseudomonas aeruginosa...
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