Article
Nonhematopoietic toll-like receptor 2 contributes to neutrophil and cardiac function impairment during polymicrobial sepsis.
Shock (Augusta, Ga.) - 1 Oct 2011
Zou Lin, Feng Yan, Zhang Ming, Li Yan, Chao Wei
Abstract excerpt
Toll-like receptor 2 (TLR2) has been implicated in neutrophil and cardiac dysfunction during sepsis. Here we tested the hypothesis that nonhematopoietic (parenchymal) and hematopoietic TLR2 play distinct roles in sepsis pathogenesis. To achieve this, we generated two groups of chimeric mice with TLR2 deletions either in nonhematopoietic cells (knockout [KO] mice with wild-type [WT] bone marrow [BM]) or in BM...
Topics
- Animals
- Animals, Newborn
- Cells, Cultured
- Flow Cytometry
- Genotype
- Immunoassay
- Male
- Mice
- Mice, Knockout
- Myocytes, Cardiac
- Neutrophils
- Peritoneal Cavity
- Rats
- Reactive Oxygen Species
- Reverse Transcriptase Polymerase Chain Reaction