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Article

MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.

The Journal of clinical investigation - 1 Dec 2021

Tilstam Pathricia Veronica, Schulte Wibke, Holowka Thomas, Kim Bong-Sung, Nouws Jessica, Sauler Maor, Piecychna Marta, Pantouris Georgios, Lolis Elias, Leng Lin, Bernhagen Jürgen, Fingerle-Rowson Günter, Bucala Richard

Abstract excerpt

Excessive inflammation drives the progression from sepsis to septic shock. Macrophage migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict mortality in different infections, and anti-MIF antibody improves survival in experimental models when administered 8 hours after infectious insult. The recent description of a second MIF superfamily member, D-dopachrome tautomerase...

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Identifiers

PMID: 34850744
DOI: 10.1172/JCI127171
PMCID: PMC8631602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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