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Article

Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention.

Essays in biochemistry - 4 Nov 2009

Rial Nathaniel S, Meyskens Frank L, Gerner Eugene W

Abstract excerpt

Combination chemoprevention for cancer was proposed a quarter of a century ago, but has not been implemented in standard medical practice owing to limited efficacy and toxicity. Recent trials have targeted inflammation and polyamine biosynthesis, both of which are increased in carcinogenesis. Preclinical studies have demonstrated that DFMO (difluoromethylornithine), an irreversible inhibitor of ODC (ornithine...

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Identifiers

PMID: 20095973
DOI: 10.1042/bse0460008
PMCID: PMC3574816

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APC

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