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Article

Early events in the binding of the pPS10 replication protein RepA to single iteron and operator DNA sequences.

Journal of molecular biology - 15 Dec 2006

Díaz-López Teresa, Dávila-Fajardo Cristina, Blaesing Franca, Lillo M Pilar, Giraldo Rafael

Abstract excerpt

RepA protein, encoded in the Pseudomonas pPS10 replicon, is a stable dimer in solution (dRepA), acting as a self-repressor of repA transcription through binding to an inverted repeat operator. However, RepA monomers (mRepA) are required to initiate plasmid replication upon binding to four directly repeated DNA sequences (iterons). RepA is composed of two winged-helix (WH) domains: C-terminal WH2 is the main...

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PMID: 17045290
DOI: 10.1016/j.jmb.2006.09.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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