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Article

Aggregation interplay between variants of the RepA-WH1 prionoid in Escherichia coli.

Journal of bacteriology - 1 Jul 2014

Molina-García Laura, Giraldo Rafael

Abstract excerpt

The N-terminal domain (winged-helix domain, or WH1) of the Pseudomonas pPS10 plasmid DNA replication protein RepA can assemble into amyloid fibers in vitro and, when expressed in Escherichia coli, leads to a unique intracellular amyloid proteinopathy by hampering bacterial proliferation. RepA-WH1 amyloidosis propagates along generations through the transmission of aggregated particles across the progeny, but it...

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Identifiers

PMID: 24794561
DOI: 10.1128/JB.01527-14
PMCID: PMC4097580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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