Article
High pressure activation of the Mrr restriction endonuclease in Escherichia coli involves tetramer dissociation.
Nucleic acids research - 19 May 2017
Bourges Anaïs C, Torres Montaguth Oscar E, Ghosh Anirban, Tadesse Wubishet M, Declerck Nathalie, Aertsen Abram, Royer Catherine A
Abstract excerpt
A sub-lethal hydrostatic pressure (HP) shock of ∼100 MPa elicits a RecA-dependent DNA damage (SOS) response in Escherichia coli K-12, despite the fact that pressure cannot compromise the covalent integrity of DNA. Prior screens for HP resistance identified Mrr (Methylated adenine Recognition and Restriction), a Type IV restriction endonuclease (REase), as instigator for this enigmatic HP-induced SOS response....
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