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Article

Defined DNA sequences promote the assembly of a bacterial protein into distinct amyloid nanostructures.

Proceedings of the National Academy of Sciences of the United States of America - 30 Oct 2007

Giraldo Rafael

Abstract excerpt

RepA, the replication initiator protein of Pseudomonas pPS10 plasmid, is made of two winged-helix (WH) domains. RepA dimers undergo a structural transformation upon binding to origin DNA sequences (iterons), resulting in monomerization and alpha-helix into beta-strand conversion. This affects the N-terminal domain (WH1) and generates a metastable intermediate. Here it is shown that the interaction of short dsDNA...

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Identifiers

PMID: 17959784
DOI: 10.1073/pnas.0702006104
PMCID: PMC2077266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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