Article
Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens.
Molecular and cellular biology - 1 May 1995
Lee Y W, Klein C B, Kargacin B, Salnikow K, Kitahara J, Dowjat K, Zhitkovich A, Christie N T, Costa M
Abstract excerpt
A transgenic gpt+ Chinese hamster cell line (G12) was found to be susceptible to carcinogenic nickel-induced inactivation of gpt expression without mutagenesis or deletion of the transgene. Many nickel-induced 6-thioguanine-resistant variants spontaneously reverted to actively express gpt, as ind...
Topics
- Animals
- Azacitidine
- Base Sequence
- Carcinogens
- Cell Line
- Chromatin
- Cricetinae
- Cricetulus
- DNA
- DNA Primers
- Drug Resistance
- Gene Expression
- Genetic Variation
- Hypoxanthine Phosphoribosyltransferase
- Methylation