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Article

Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens.

Molecular and cellular biology - 1 May 1995

Lee Y W, Klein C B, Kargacin B, Salnikow K, Kitahara J, Dowjat K, Zhitkovich A, Christie N T, Costa M

Abstract excerpt

A transgenic gpt+ Chinese hamster cell line (G12) was found to be susceptible to carcinogenic nickel-induced inactivation of gpt expression without mutagenesis or deletion of the transgene. Many nickel-induced 6-thioguanine-resistant variants spontaneously reverted to actively express gpt, as indicated by both reversion assays and direct enzyme measurements. Since reversion was enhanced in many of the...

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Identifiers

PMID: 7537850
DOI: 10.1128/MCB.15.5.2547
PMCID: PMC230485

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