Article
Distal heme pocket conformers of carbonmonoxy derivatives of Ascaris hemoglobin: evidence of conformational trapping in porous sol-gel matrices.
The Journal of biological chemistry - 12 Mar 2004
Das Tapan K, Samuni Uri, Lin Yu, Goldberg Daniel E, Rousseau Denis L, Friedman Joel M
Abstract excerpt
We report the ligand dependence of the conformer distribution in the distal heme pocket of Ascaris suum hemoglobin (Hb) studied by resonance Raman spectroscopy. The heme-bound CO is used as a spectroscopic antenna to probe the original distribution of conformers in the dioxygen derivative of Ascaris Hb, by utilizing sol-gel encapsulation. The first step is to encapsulate the dioxygen derivative in the porous...
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