The structural link between polymerization and sickle cell disease.

Abstract excerpt

Sickle hemoglobin molecules assemble into polymers composed of seven helically twisted double strands. Intermolecular contacts involving the mutation sites within the double strands are well established. We show that the same contact sites are present at the polymer surface on four of the ten ext...

Topics

• Anemia, Sickle Cell
• Binding Sites
• Biophysical Phenomena
• Biophysics
• Biopolymers
• Cross-Linking Reagents
• Gels
• Hemoglobin, Sickle
• Humans
• Kinetics
• Models, Molecular
• Molecular Structure
• Mutation
• Surface Properties