Article
The effects of cAMP on differentiation of cultured Schwann cells: progression from an early phenotype (04+) to a myelin phenotype (P0+, GFAP-, N-CAM-, NGF-receptor-) depends on growth inhibition.
The Journal of cell biology - 1 Feb 1991
Morgan L, Jessen K R, Mirsky R
Abstract excerpt
The present experiments were designed to clarify the relationship between cAMP elevation, proliferation and differentiation in Schwann cells. They were carried out on short-term cultures of cells obtained from neonatal rat sciatic nerves. It was found that the myelin-related phenotype was express...
Topics
- 1-Methyl-3-isobutylxanthine
- Animals
- Animals, Newborn
- Cell Adhesion Molecules, Neuronal
- Cell Differentiation
- Cell Division
- Cholera Toxin
- Colforsin
- Cyclic AMP
- Glial Fibrillary Acidic Protein
- Membrane Glycoproteins
- Myelin P0 Protein
- Myelin Proteins
- Nerve Growth Factors