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Article

Divergent regulation of GAP-43 expression and CNS neurite outgrowth by cyclic AMP.

Journal of neuroscience research - 15 Sept 2000

Andersen P L, Webber C A, Whittemore S R, Schreyer D J

Abstract excerpt

Robust process outgrowth and high expression of the growth-associated protein GAP-43 seem to be intrinsic features of neurons, but both are down-regulated after axonal contact of target cells. We report that chronic exposure of the serotonergic CNS cell line RN46A to cyclic AMP analogs, forskolin, or cholera toxin represses GAP-43 expression in a dose dependent manner. Thus, cAMP could mediate a GAP-43 repressive...

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Identifiers

PMID: 10972959
DOI: 10.1002/1097-4547(20000915)61:6<626::AID-JNR6>3.0.CO;2-J

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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