Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclin-dependent kinase inhibitor p27kip1 is expressed at high levels in cells that express a myelinating phenotype.

Journal of neuroscience research - 1 Nov 1997

Friessen A J, Miskimins W K, Miskimins R

Abstract excerpt

Terminal cellular differentiation is generally accompanied by exit from the cell cycle but the molecular basis of how the two events are coupled is poorly understood. In the central nervous system (CNS) the terminally differentiated, non-proliferating myelin-synthesizing cells, oligodendrocytes, arise from stem cells that are proliferation competent. To study the molecular mechanisms that link oligodendrocyte...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Cell Cycle
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Division

Share to Cell Line

Share to Cells, Cultured

Share to Cyclic AMP

Share to Kinetics

Source

Identifiers

PMID: 9364322
DOI: 10.1002/(SICI)1097-4547(19971101)50:3<373::AID-JNR3>3.0.CO;2-F

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclin-dependent kinase inhibitor p27kip1 is expressed at high levels in cells that express a myelinating phenotype.PMID 9364322Read ↗

p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal.Semantic proximity Read ↗

p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation.Semantic proximity Read ↗

The effects of cAMP on differentiation of cultured Schwann cells: progression from an early phenotype (04+) to a myelin phenotype (P0+, GFAP-, N-CAM-, NGF-receptor-) depends on growth inhibition.Semantic proximity Read ↗

Astroglial differentiation of cortical precursor cells triggered by activation of the cAMP-dependent signaling pathway.Semantic proximity Read ↗

Autocrine inhibition of mitotic activity in cultured oligodendrocyte-type-2 astrocyte (O-2A) precursor cells.Semantic proximity Read ↗

Neurotransmitter receptor activation triggers p27(Kip1 )and p21(CIP1) accumulation and G1 cell cycle arrest in oligodendrocyte progenitors.Semantic proximity Read ↗

Mitogen-activated protein kinase signalling in oligodendrocytes: a comparison of primary cultures and CG-4.Semantic proximity Read ↗

Cell cycle events in neurons. Proliferation or death?Semantic proximity Read ↗

Non-antagonistic relationship between mitogenic factors and cAMP in adult Schwann cell re-differentiation.Semantic proximity Read ↗

E Proteins and Id2 Converge on p57<sup>Kip2</sup> To Regulate Cell Cycle in Neural CellsSemantic proximity Read ↗

Neonatal and adult O4<sup>+</sup> oligodendrocyte lineage cells display different growth factor responses and different gene expression patternsSemantic proximity Read ↗

p27Kip1 Regulates Cell Cycle Withdrawal of Late Multipotent Progenitor Cells in the Mammalian RetinaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.