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Article

PTPN22 620W allele is not associated with aplastic anemia.

American journal of hematology - 1 Apr 2007

Graf Solomon A, Calado Rodrigo T, Young Neal S

Abstract excerpt

The 1858C/T variant in PTPN22 imparts a gain of function mutation dysregulating T-cell stimulation and is associated with an array of autoimmune diseases. Using a case-control design, we compared the frequency of this polymorphism in 91 patients with acquired aplastic anemia to 132 ethnically matched controls. Representation of the PTPN22 variant was not significantly different between the two populations,...

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Source

Identifiers

PMID: 17034023
DOI: 10.1002/ajh.20768

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTPN22 620W allele is not associated with aplastic anemia.PMID 17034023Read ↗

The PTPN22*R620W polymorphism does not confer genetic susceptibility to antiphospholipid syndrome in the Spanish population.Semantic proximity Read ↗

The PTPN22 620W allele is a risk factor for Wegener's granulomatosis.Semantic proximity Read ↗

Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease.Semantic proximity Read ↗

PTPN22 1858T is not a risk factor for North American pemphigus vulgaris.Semantic proximity Read ↗

Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population.Semantic proximity Read ↗

Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population.Semantic proximity Read ↗

PTPN22 R620W polymorphism and ANCA disease risk in white populations: a metaanalysis.Semantic proximity Read ↗

PTPN22 R620W polymorphism in the ANCA-associated vasculitides.Semantic proximity Read ↗

PTPN22: setting thresholds for autoimmunity.Semantic proximity Read ↗

PTPN22 is not associated with Behçet's disease. Study spanning the complete gene region in the Spanish population and meta-analysis of the functional variant R620W.Semantic proximity Read ↗

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes.Semantic proximity Read ↗

The PTPN22 R620W polymorphism is associated with severe bacterial infections after human leukocyte antigen geno-identical haematopoietic stem-cell transplantations.Semantic proximity Read ↗

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