PTPN22 R620W polymorphism in the ANCA-associated vasculitides.

doi:10.1093/rheumatology/ker446

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Article

PTPN22 R620W polymorphism in the ANCA-associated vasculitides.

Rheumatology (Oxford, England) - 1 May 2012

Martorana Davide, Maritati Federica, Malerba Giovanni, Bonatti Francesco, Alberici Federico, Oliva Elena, Sebastio Paola, Manenti Lucio, Brugnano Rachele, Catanoso Maria G, Fraticelli Paolo, Guida Giuseppe, Gregorini Gina, Possenti Stefano, Moroni Gabriella, Leoni Antonio, Pavone Laura, Pesci Alberto, Sinico Renato A, Di Toma Lucafrancesco, D'Amico Marco, Tumiati Bruno, D'Ippolito Raffaele, Buzio Carlo, Neri Tauro M, Vaglio Augusto

Abstract excerpt

OBJECTIVES: PTPN22 is involved in T-cell activation and its R620W single-nucleotide polymorphism (SNP) has been shown to predispose to different autoimmune diseases. The aims of this study were to investigate the role of the PTPN22 R620W SNP in conferring susceptibility to the ANCA-associated vasculitides (AAVs), and to explore potential associations between the PTPN22 genotype and the disease manifestations....

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PMID: 22237046
DOI: 10.1093/rheumatology/ker446

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PTPN22

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