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Article

Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population.

Rheumatology (Oxford, England) - 1 Nov 2006

Ikari K, Momohara S, Inoue E, Tomatsu T, Hara M, Yamanaka H, Kamatani N

Abstract excerpt

OBJECTIVE: The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene is a member of the PTPs that negatively regulate T-cell activation. A missense single nucleotide polymorphism (SNP) in the PTPN22 gene known as R620W was recently reported to be associated with several autoimmune disea...

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Source

Identifiers

PMID: 16690758
DOI: 10.1093/rheumatology/kel169

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16690758-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population.PMID 16690758Read ↗

PTPN22 polymorphisms, but not R620W, were associated with the genetic susceptibility of systemic lupus erythematosus and rheumatoid arthritis in a Chinese Han population.Semantic proximity Read ↗

PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis.Semantic proximity Read ↗

PTPN22 gene polymorphism and susceptibility to rheumatoid arthritis (RA): Updated systematic review and meta-analysis.Semantic proximity Read ↗

1858 C/T polymorphism of the protein tyrosine phosphatase nonreceptor 22 gene and rheumatoid arthritis risk in europeans: a meta-analysis.Semantic proximity Read ↗

No association of PTPN22 gene polymorphism with rheumatoid arthritis in Turkey.Semantic proximity Read ↗

The R620W polymorphism of the protein tyrosine phosphatase 22 gene in autoimmune thyroid diseases and rheumatoid arthritis in the Tunisian population.Semantic proximity Read ↗

The PTPN22 locus and rheumatoid arthritis: no evidence for an effect on risk independent of Arg620Trp.Semantic proximity Read ↗

Association of the PTPN22 gene (-1123G > C) polymorphism with rheumatoid arthritis in Chinese patients.Semantic proximity Read ↗

Evidence for PTPN22 R620W polymorphism as the sole common risk variant for rheumatoid arthritis in the 1p13.2 region.Semantic proximity Read ↗

Association of PTPN22 haplotypes with type 1 diabetes in the Japanese population.Semantic proximity Read ↗

The PTPN22 promoter polymorphism -1123G>C association cannot be distinguished from the 1858C>T association in a Norwegian rheumatoid arthritis material.Semantic proximity Read ↗

Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond.Semantic proximity Read ↗

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