Article
Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease.
Arthritis and rheumatism - 1 Aug 2005
Wu Hui, Cantor Rita M, Graham Deborah S Cunninghame, Lingren Cecilia M, Farwell Lisa, Jager Philip L De, Bottini Nunzio, Grossman Jennifer M, Wallace Daniel J, Hahn Bevra H, Julkunen Heikki, Hebert Lee A, Rovin Brad H, Birmingham Dan J, Rioux John D, Yu C Yung, Kere Juha, Vyse Timothy J, Tsao Betty P
Abstract excerpt
OBJECTIVE: Recent case-control studies show associations of the minor T allele (of the C1858T single-nucleotide polymorphism corresponding to the R620W amino acid substitution) of PTPN22 with multiple autoimmune diseases, including systemic lupus erythematosus (SLE). We performed family-based association studies of this polymorphism in 4 independent cohorts containing SLE patients and their parents and/or other...
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