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Signature-Tagged Transposon Mutagenesis Identifies Novel <i>Mycobacterium tuberculosis</i> Genes Involved in the Parasitism of Human Macrophages

20 Dec 2006

Abstract excerpt

Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.

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PMID: 17030567
DOI: 10.1128/iai.00058-06

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