Article
A transposon insertion mutant of Mycobacterium fortuitum attenuated in virulence and persistence in a murine infection model that is complemented by Rv3291c of Mycobacterium tuberculosis.
Microbial pathogenesis - 1 Jan 2000
Parti R P S, Shrivastava Rahul, Srivastava S, Subramanian A R, Roy Raja, Srivastava Brahm S, Srivastava Ranjana
Abstract excerpt
Mycobacterium fortuitum is a non-tubercular fast growing pathogenic mycobacteria whose virulence factors have not been studied. Infection of M. fortuitum ATCC 6841 in a murine infection model leads to spinning of the head in 8-12 days after infection, 20-25% mortality and a constant bacillary load in the kidney of mice, suggesting persistence. From a TnphoA insertion library, a mutant MT13 was isolated which was...
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