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Designer Arrays for Defined Mutant Analysis To Detect Genes Essential for Survival of <i>Mycobacterium tuberculosis</i> in Mouse Lungs

22 Mar 2005

Abstract excerpt

The mechanisms by which Mycobacterium tuberculosis elicits disease are complex, involving a large repertoire of bacterial genes that are required for in vivo growth and survival. To identify such genes, we utilized a high-throughput microarray detection method to rapidly screen hundreds of unique, genotypically defined transposon mutants for in vivo survival with a high degree of specificity and sensitivity....

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PMID: 15784600
DOI: 10.1128/iai.73.4.2533-2540.2005

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