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Article

Myosin regulatory light chain mutation found in hypertrophic cardiomyopathy patients increases isometric force production in transgenic mice.

The Biochemical journal - 15 Feb 2012

Kazmierczak Katarzyna, Muthu Priya, Huang Wenrui, Jones Michelle, Wang Yingcai, Szczesna-Cordary Danuta

Abstract excerpt

FHC (familial hypertrophic cardiomyopathy) is a heritable form of cardiac hypertrophy caused by mutations in genes encoding sarcomeric proteins. The present study focuses on the A13T mutation in the human ventricular myosin RLC (regulatory light chain) that is associated with a rare FHC variant defined by mid-ventricular obstruction and septal hypertrophy. We generated heart-specific Tg (transgenic) mice with...

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Identifiers

PMID: 22091967
DOI: 10.1042/BJ20111145
PMCID: PMC6589164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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