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Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease

7 Oct 2006

Abstract excerpt

Secretory phospholipase A2-IIA (sPLA2-IIA) is an inflammatory protein known to play a role in the pathogenesis of many inflammatory diseases. Although this enzyme has also been implicated in the pathogenesis of neurodegenerative diseases, there has not been a direct demonstration of its expression in diseased human brain. In this study, we show that sPLA2-IIA mRNA is up-regulated in Alzheimer's disease (AD)...

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PMID: 17026770
DOI: 10.1186/1742-2094-3-28

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