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Article

The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis.

Annals of neurology - 1 Sept 2008

Liang Xibin, Wang Qian, Shi Ju, Lokteva Ludmila, Breyer Richard M, Montine Thomas J, Andreasson Katrin

Abstract excerpt

OBJECTIVE: Inflammation has emerged as an important factor in disease progression in human and transgenic models of amyotrophic lateral sclerosis (ALS). Recent studies demonstrate that the prostaglandin E(2) EP2 receptor is a major regulator of inflammatory oxidative injury in innate immunity. We tested whether EP2 signaling participated in disease pathogenesis in the G93A superoxide dismutase (SOD) model of...

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Identifiers

PMID: 18825663
DOI: 10.1002/ana.21437
PMCID: PMC2766522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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