Article
Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 1999
Ivandic B, Castellani L W, Wang X P, Qiao J H, Mehrabian M, Navab M, Fogelman A M, Grass D S, Swanson M E, de Beer M C, de Beer F, Lusis A J
Abstract excerpt
Some observations have suggested that the extracellular group IIa phospholipase A2 (sPLA2), previously implicated in chronic inflammatory conditions such as arthritis, may contribute to atherosclerosis. We have examined this hypothesis by studying transgenic mice expressing the human enzyme. Compared with nontransgenic littermates, the transgenic mice exhibited dramatically increased atherosclerotic lesions when...
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