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Regulation of type V phospholipase A<sub>2</sub> expression and function by proinflammatory stimuli

1 Aug 1999

Abstract excerpt

Types IIA and V secretory phospholipase A2 (sPLA2) are structurally related to each other and their genes are tightly linked to the same chromosome locus. An emerging body of evidence suggests that sPLA2-IIA plays an augmentative role in long-term prostaglandin (PG) generation in cells activated by proinflammatory stimuli; however, the mechanism underlying the functional regulation of sPLA2-V remains largely...

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PMID: 10469147
DOI: 10.1046/j.1432-1327.1999.00565.x

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