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Article

Human group X secreted phospholipase A2 induces dendritic cell maturation through lipoprotein-dependent and -independent mechanisms.

Atherosclerosis - 1 Jun 2012

Atout Rajai, Karabina Sonia-Athina, Dollet Sandra, Carreras Martine, Payré Christine, André Patrice, Lambeau Gérard, Lotteau Vincent, Ninio Ewa, Perrin-Cocon Laure

Abstract excerpt

OBJECTIVE: Increased secreted phospholipase A(2) (sPLA(2)) activity has been documented in several inflammatory disorders. Among sPLA(2)s, the human group X (hGX)-sPLA(2) has the highest catalytic activity towards phosphatidylcholine (PC), the major phospholipid of cell membranes and blood lipoproteins. hGX-sPLA(2) has been detected in human atherosclerotic lesions, indicating that sPLA(2)s are an important link...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22494626
DOI: 10.1016/j.atherosclerosis.2012.03.014

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