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Article

Group IIa secretory phospholipase expression correlates with group IIa secretory phospholipase inhibition-mediated cell death in K-ras mutant lung cancer cells.

The Journal of thoracic and cardiovascular surgery - 1 Dec 2012

Yu Jessica A, Li Howard, Meng Xianzhong, Fullerton David A, Nemenoff Raphael A, Mitchell John D, Weyant Michael J

Abstract excerpt

OBJECTIVE: There are currently no targeted therapies against lung tumors with oncogenic K-ras mutations that are found in 25% to -40% of lung cancers and are characterized by their resistance to epidermal growth factor receptor inhibitors. The isozyme group IIa secretory phospholipase A(2) (sPLA(2)IIa) is a potential biomarker and regulator of lung cancer cell invasion; however, the relationship between K-ras...

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Identifiers

PMID: 23026567
DOI: 10.1016/j.jtcvs.2012.08.064
PMCID: PMC3855847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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